Article
Mutations in the beta1 adrenergic receptor gene and massive obesity in Japanese.
Diabetes research and clinical practice - 1 May 2008
Ohshiro Yuzuru, Hayashi Mina, Yabiku Koichi, Ueda Kazuya, Wakasaki Hisao, Ishigame Masayuki, Furuta Hiroto, Nishi Masahiro, Sasaki Hideyuki, Takasu Nobuyuki, Nanjo Kishio
Abstract excerpt
Catecholamines strongly promote lipolysis and thermogenesis, and play a central role in the regulation of body fat content. The beta1 adrenergic receptor (BAR-1) is a major mediator of catecholamine-induced lipolysis and thermogenesis. To explore whether mutations in the BAR-1 gene contribute to...
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