Article
Genetic variation in the beta 3-adrenergic receptor and an increased capacity to gain weight in patients with morbid obesity.
The New England journal of medicine - 10 Aug 1995
Clément K, Vaisse C, Manning B S, Basdevant A, Guy-Grand B, Ruiz J, Silver K D, Shuldiner A R, Froguel P, Strosberg A D
Abstract excerpt
BACKGROUND: The beta 3-adrenergic receptor, located mainly in adipose tissue, is involved in the regulation of lipolysis and thermogenesis. The potential relevance of this receptor to obesity in humans led us to screen obese French patients for a recently identified mutation in the gene for the r...
Topics
- Adult
- Aged
- Base Sequence
- Case-Control Studies
- Female
- Genotype
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Obesity, Morbid
- Pedigree
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length