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Article

Mutant B-Raf(V600E) Promotes Melanoma Paracellular Transmigration by Inducing Thrombin-mediated Endothelial Junction Breakdown.

The Journal of biological chemistry - 29 Jan 2016

Zhang Pu, Feng Shan, Liu Gentao, Wang Heyong, Zhu Huifeng, Ren Qiao, Bai Huiyuan, Fu Changliang, Dong Cheng

Abstract excerpt

Tumor invasiveness depends on the ability of tumor cells to breach endothelial barriers. In this study, we investigated the mechanism by which the adhesion of melanoma cells to endothelium regulates adherens junction integrity and modulates tumor transendothelial migration (TEM) by initiating thrombin generation. We found that the B-Raf(V600E) mutation in metastatic melanoma cells up-regulated tissue factor (TF)...

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Identifiers

PMID: 26504080
DOI: 10.1074/jbc.M115.696419
PMCID: PMC4732197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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