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Article

Melanocyte transformation associated with substrate adhesion impediment.

Neoplasia (New York, N.Y.) - 1 Mar 2006

Oba-Shinjo Sueli M, Correa Mariangela, Ricca Tatiana I, Molognoni Fernanda, Pinhal Maria A, Neves Izabel A, Marie Sueli K, Sampaio Lúcia O, Nader Helena B, Chammas Roger, Jasiulionis Miriam G

Abstract excerpt

Exclude experimental models of malignant transformation employ chemical and physical carcinogens or genetic manipulations to study tumor progression. In this work, different melanoma cell lines were established after submitting a nontumorigenic melanocyte lineage (melan-a) to sequential cycles of forced anchorage impediment. The great majority of these cells underwent anoikis when maintained in suspension. After...

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Identifiers

PMID: 16611417
DOI: 10.1593/neo.05781
PMCID: PMC1578519

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Source receipt: pubmed, retrieved 7 Sept 2026.

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