Article
Integrins and cancer.
Oncology (Williston Park, N.Y.) - 1 Aug 2007
Moschos Stergios J, Drogowski Laura M, Reppert Shelley L, Kirkwood John M
Abstract excerpt
Integrins play an important physiologic role in cell adhesion, and accumulating evidence suggests that they also regulate cell growth, proliferation, migration, and apoptosis. A number of congenital and acquired disease states have been associated with integrins, and small-molecule integrin inhibitors have been approved for treatment of benign hematologic diseases. In cancer, aberrant expression with...
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