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Article

Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast.

Molecular cell - 1 Jun 2003

Düvel Katrin, Santhanam Arti, Garrett Stephen, Schneper Lisa, Broach James R

Abstract excerpt

Tor proteins, targets of the antiinflammatory drug rapamycin, mediate a conserved signaling pathway required for cell growth and proliferation in eukaryotes. By global transcriptional analysis of Saccharomyces cerevisiae, we have examined the role of the essential protein Tap42 in transcriptional regulation by Tor. We find that Tap42 inactivation, like rapamycin addition, prolongs activation of stress response...

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Identifiers

PMID: 12820961
DOI: 10.1016/s1097-2765(03)00228-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Multiple roles of Tap42 in mediating rapamycin-induced transcriptional changes in yeast.PMID 12820961Read ↗

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Target of rapamycin complex 1 and Tap42-associated phosphatases are required for sensing changes in nitrogen conditions in the yeast Saccharomyces cerevisiae.Semantic proximity Read ↗

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