Article
The phosphatase subunit tap42 functions independently of target of rapamycin to regulate cell division and survival in Drosophila.
Genetics - 1 Jun 2005
Cygnar Katherine D, Gao Xinsheng, Pan Duojia, Neufeld Thomas P
Abstract excerpt
The protein phosphatase 2A (PP2A) regulatory subunit Tap42 is essential for target of rapamycin (TOR)-mediated signaling in yeast, but its role in higher eukaryotes has not been established. Here we show that Tap42 does not contribute significantly to TOR signaling in Drosophila, as disruption of the Tap42 gene does not cause defects in cell growth, metabolism, or S6-kinase activity characteristic of TOR...
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