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Article

Role of Streptolysin O in a Mouse Model of Invasive Group A Streptococcal Disease

1 Nov 2000

Abstract excerpt

Many of the virulence factors that have been characterized for group A streptococci (GAS) are not expressed in all clinical isolates. One putative virulence factor that is present among most is streptolysin O (Slo), a protein with well-characterized cytolytic activity for many eukaryotic cells types. In other bacterial pathogens, proteins homologous to Slo have been shown to be essential for virulence, but the...

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PMID: 11035749
DOI: 10.1128/iai.68.11.6384-6390.2000

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