Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gender specific LRP5 influences on trabecular bone structure and strength.

Journal of musculoskeletal & neuronal interactions - 1 Jan 2000

Dubrow S A, Hruby P M, Akhter M P

Abstract excerpt

A mutation in LRP5 (low-density lipoprotein receptor-related protein 5) has been shown to increase bone mass and density in humans and animals. Transgenic mice expressing the LRP5 mutation (G171V) demonstrate an increase in bone mass as compared to non-transgenic (NTG) littermates. This study evaluated LRP5 gene and gender-related influences on the structural and biomechanical strength properties of trabecular...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone and Bones
Share to Bone Regeneration
Share to Femur

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to LDL-Receptor Related Proteins

Share to Low Density Lipoprotein Receptor-Related Protein-5

Share to Stress, Mechanical

Share to Weight-Bearing

Source

Identifiers

PMID: 17627087

Genes

LRP5

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gender specific LRP5 influences on trabecular bone structure and strength.PMID 17627087Read ↗

High Bone Mass in Mice Expressing a Mutant <i>LRP5</i> GeneSemantic proximity Read ↗

Bone biomechanical properties in LRP5 mutant mice.Semantic proximity Read ↗

The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation.Semantic proximity Read ↗

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it.Semantic proximity Read ↗

The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration.Semantic proximity Read ↗

Disuse-related decline in trabecular bone structure.Semantic proximity Read ↗

Lrp5 functions in bone to regulate bone mass.Semantic proximity Read ↗

HBM Mice Have Altered Bone Matrix Composition and Improved Material Toughness.Semantic proximity Read ↗

Lrp5 A241T High-Bone-Mass Mutation Enhances Implant Osseointegration: An Experimental Murine Study.Semantic proximity Read ↗

Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner.Semantic proximity Read ↗

LRP5 and bone mass regulation: Where are we now?Semantic proximity Read ↗

Pathogenic mutations and polymorphisms in the lipoprotein receptor-related protein 5 reveal a new biological pathway for the control of bone mass.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.