Article
A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.
American journal of human genetics - 1 Jan 2002
Little Randall D, Carulli John P, Del Mastro Richard G, Dupuis Josée, Osborne Mark, Folz Colleen, Manning Susan P, Swain Pamela M, Zhao Shan-Chuan, Eustace Brenda, Lappe Michelle M, Spitzer Lia, Zweier Susan, Braunschweiger Karen, Benchekroun Youssef, Hu Xintong, Adair Ronald, Chee Linda, FitzGerald Michael G, Tulig Craig, Caruso Anthony, Tzellas Nia, Bawa Alicia, Franklin Barbara, McGuire Shannon, Nogues Xavier, Gong Gordon, Allen Kristina M, Anisowicz Anthony, Morales Arturo J, Lomedico Peter T, Recker Susan M, Van Eerdewegh Paul, Recker Robert R, Johnson Mark L
Abstract excerpt
Osteoporosis is a complex disease that affects >10 million people in the United States and results in 1.5 million fractures annually. In addition, the high prevalence of osteopenia (low bone mass) in the general population places a large number of people at risk for developing the disease. In an effort to identify genetic factors influencing bone density, we characterized a family that includes individuals who...
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