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Article

Bone biomechanical properties in LRP5 mutant mice.

Bone - 1 Jul 2004

Akhter M P, Wells D J, Short S J, Cullen D M, Johnson M L, Haynatzki G R, Babij P, Allen K M, Yaworsky P J, Bex F, Recker R R

Abstract excerpt

The mutation responsible for the high bone mass (HBM) phenotype has been postulated to act through the adaptive response of bone to mechanical load resulting in denser and stronger skeletons in humans and animals. The bone phenotype of members of a HBM family is characterized by normally shaped b...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15207752
DOI: 10.1016/j.bone.2004.02.018

Genes

LRP5
HBM

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15207752-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

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Bone biomechanical properties in LRP5 mutant mice.PMID 15207752Read ↗

High Bone Mass in Mice Expressing a Mutant <i>LRP5</i> GeneSemantic proximity Read ↗

HBM Mice Have Altered Bone Matrix Composition and Improved Material Toughness.Semantic proximity Read ↗

Gender specific LRP5 influences on trabecular bone structure and strength.Semantic proximity Read ↗

Analysis of multiple bone responses to graded strains above functional levels, and to disuse, in mice in vivo show that the human Lrp5 G171V High Bone Mass mutation increases the osteogenic response to loading but that lack of Lrp5 activity reduces it.Semantic proximity Read ↗

The high-bone-mass phenotype of novel transgenic mice with LRP5 A241T mutation.Semantic proximity Read ↗

Mechanotransduction in bone tissue: The A214V and G171V mutations in Lrp5 enhance load-induced osteogenesis in a surface-selective manner.Semantic proximity Read ↗

The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration.Semantic proximity Read ↗

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Lrp5 functions in bone to regulate bone mass.Semantic proximity Read ↗

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Targeting the LRP5 pathway improves bone properties in a mouse model of osteogenesis imperfecta.Semantic proximity Read ↗

A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait.Semantic proximity Read ↗

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