Article
Bone biomechanical properties in LRP5 mutant mice.
Bone - 1 Jul 2004
Akhter M P, Wells D J, Short S J, Cullen D M, Johnson M L, Haynatzki G R, Babij P, Allen K M, Yaworsky P J, Bex F, Recker R R
Abstract excerpt
The mutation responsible for the high bone mass (HBM) phenotype has been postulated to act through the adaptive response of bone to mechanical load resulting in denser and stronger skeletons in humans and animals. The bone phenotype of members of a HBM family is characterized by normally shaped bones that are exceptionally dense, particularly at load bearing sites [Cancer Res. 59 (1999) 1572]. The high bone mass...
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