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Article

Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine.

Neuroscience letters - 10 May 2013

Clarke Toni-Kim, Crist Richard C, Kampman Kyle M, Dackis Charles A, Pettinati Helen M, O'Brien Charles P, Oslin David W, Ferraro Thomas N, Lohoff Falk W, Berrettini Wade H

Abstract excerpt

The μ-opioid receptor (MOR) binds exogenous and endogenous opioids and is known to mediate the rewarding effects of drugs of abuse. Numerous genetic studies have sought to identify common genetic variation in the gene encoding MOR (OPRM1) that affects risk for drug addiction. The purpose of this study was to examine the contribution of rare coding variants in OPRM1 to the risk for addiction. Rare and low...

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Identifiers

PMID: 23454283
DOI: 10.1016/j.neulet.2013.02.018
PMCID: PMC3640707

Genes

OPRM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Low frequency genetic variants in the μ-opioid receptor (OPRM1) affect risk for addiction to heroin and cocaine.PMID 23454283Read ↗

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Novel exonic mu-opioid receptor gene (OPRM1) polymorphisms not associated with opioid dependence.Semantic proximity Read ↗

Cis-Expression Quantitative Trait Loci Mapping Reveals Replicable Associations with Heroin Addiction in OPRM1.Semantic proximity Read ↗

Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.Semantic proximity Read ↗

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