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Article

Pregnancy in mice lacking the vitamin D receptor: normal maternal skeletal response, but fetal hypomineralization rescued by maternal calcium supplementation.

Pediatric research - 1 Oct 2003

Rummens Katrien, van Cromphaut Sophie J, Carmeliet Geert, van Herck Erik, van Bree Rita, Stockmans Ingrid, Bouillon Roger, Verhaeghe Johan

Abstract excerpt

Fetal mineralization appears to be driven by the pregnancy-induced stimulation of intestinal Ca absorption. We thus hypothesized that mineralization would be impaired in fetuses of mice that lack the vitamin D receptor (VDR). Here we report on the maternal response to pregnancy, and the fetal mineralization, in mice with a homozygous disruption of the VDR gene (VDR-/-) mated with wild-type (wt) males. We found...

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Source

Identifiers

PMID: 12815117
DOI: 10.1203/01.PDR.0000081302.06915.D3

Genes

VDR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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