Article
Accelerated mammary gland development during pregnancy and delayed postlactational involution in vitamin D3 receptor null mice.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 2004
Zinser Glendon M, Welsh JoEllen
Abstract excerpt
The vitamin D receptor (VDR) is present in mammary gland, and VDR ablation is associated with accelerated glandular development during puberty. VDR is a nuclear receptor whose ligand, 1,25-dihydroxyvitamin D [1,25-(OH)(2)D] is generated after metabolic activation of vitamin D by specific vitamin D hydroxylases. In these studies, we demonstrate that both the VDR and the vitamin D 1-alpha hydroxylase (CYP27B1),...
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