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Article

Sex-related differences in the skeletal phenotype of aged vitamin D receptor global knockout mice.

The Journal of steroid biochemistry and molecular biology - 1 Nov 2016

Ryan Jackson W, Starczak Yolandi, Tsangari Helen, Sawyer Rebecca K, Davey Rachel A, Atkins Gerald J, Morris Howard A, Anderson Paul H

Abstract excerpt

The role of the vitamin D receptor (VDR) in maintaining skeletal health appears to be complex and dependent on the physiological context. Global Vdr deletion in a mouse model (Vdr-/-) results in hypocalcemia, secondary hyperparathyroidism and bone features typical of vitamin D-dependent rickets type II. When weanling Vdr-/- mice are fed a diet containing high levels of calcium, phosphorus and lactose, termed the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26690785
DOI: 10.1016/j.jsbmb.2015.12.005

Genes

VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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