Article

Coactivator-independent vitamin D receptor signaling causes severe rickets in mice, which is not prevented by a diet high in calcium, phosphate, and lactose

2024-04-03

Abstract excerpt

<title>Abstract</title> <p>The vitamin D receptor (VDR) plays a critical role in the regulation of mineral and bone homeostasis. Upon binding of 1α,25-dihydroxyvitamin D3 to the VDR, the activation function 2 (AF2) domain repositions and recruits coactivators for the assembly of the transcriptional machinery required for gene transcription. In contrast to coactivator-induced transcriptional activation, the functi...

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Literature Corpus work: 73d3a454-8cbf-53fd-b278-c55d2d18cb3b
DOI: 10.21203/rs.3.rs-4172086/v1

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Coactivator-independent vitamin D receptor signaling causes severe rickets in mice, which is not prevented by a diet high in calcium, phosphate, and lactoseDOI 10.21203/rs.3.rs-4172086/v1Read

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