Article
High dietary vitamin D prevents hypocalcemia and osteomalacia in CYP27B1 knockout mice.
The Journal of nutrition - 1 Dec 2007
Rowling Matthew J, Gliniak Christy, Welsh JoEllen, Fleet James C
Abstract excerpt
Mice lacking 25-hydroxycholecalciferol [25(OH)D]-1alpha-hydroxylase (CYP27B1) are growth retarded, hypocalcemic, and have poor bone mineralization. We tested whether high dietary cholecalciferol (VD3) could exert effects in the absence of CYP27B1 in vivo. Weanling male wild-type (WT) and CYP27B1 knockout (KO) mice were fed either a 2% calcium (Ca), 20% lactose rescue diet or an AIN93G diet (0.5% Ca, 0.4%...
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