Article
Human immunodeficiency virus-1 acquisition in genital mucosa: Langerhans cells as key-players.
Journal of internal medicine - 1 Jan 2009
de Jong M A W P, Geijtenbeek T B H
Abstract excerpt
Human immunodeficiency virus-1 (HIV-1) infection occurs primarily via genital mucosal tissues and the cellular mechanisms that affect HIV-1 acquisition are largely unclear. Langerhans cells (LCs) are professional antigen presenting cells lining the mucosal stratified squamous epithelium. It is becoming evident that LCs have different functions in HIV-1 transmission. HIV-1 can infect mucosal LCs, which...
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