Article
Genetic variation within human immunodeficiency viruses generates rapid changes in tropism, virulence, and transmission.
Leukemia - 1 Apr 1997
Essex M, Soto-Ramirez L E, Renjifo E, Wang W K, Lee T H
Abstract excerpt
The human immunodeficiency viruses (HIV-1) undergo high rates of variation. Only a few point mutations in the envelope gene are required to switch the tropism of HIV-1 from a growth preference for monocytes to lymphocytes or to acquire lytic properties for rapid killing of infected T4 lymphocytes...
Topics
- Acquired Immunodeficiency Syndrome
- Africa
- Asia
- Disease Susceptibility
- Europe
- Female
- Genes, env
- Genetic Variation
- HIV-1
- Humans
- Male
- Point Mutation
- Sexual Behavior