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Article

Genetic variation within human immunodeficiency viruses generates rapid changes in tropism, virulence, and transmission.

Leukemia - 1 Apr 1997

Essex M, Soto-Ramirez L E, Renjifo E, Wang W K, Lee T H

Abstract excerpt

The human immunodeficiency viruses (HIV-1) undergo high rates of variation. Only a few point mutations in the envelope gene are required to switch the tropism of HIV-1 from a growth preference for monocytes to lymphocytes or to acquire lytic properties for rapid killing of infected T4 lymphocytes. Since heterosexual transmission efficiency is high for HIV-1's that are most prevalent in Africa or Asia, but low for...

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PMID: 9209309

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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