CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms.

doi:10.1038/ni1521

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Article

CCL3L1 and CCR5 influence cell-mediated immunity and affect HIV-AIDS pathogenesis via viral entry-independent mechanisms.

Nature immunology - 1 Dec 2007

Dolan Matthew J, Kulkarni Hemant, Camargo Jose F, He Weijing, Smith Alison, Anaya Juan-Manuel, Miura Toshiyuki, Hecht Frederick M, Mamtani Manju, Pereyra Florencia, Marconi Vincent, Mangano Andrea, Sen Luisa, Bologna Rosa, Clark Robert A, Anderson Stephanie A, Delmar Judith, O'Connell Robert J, Lloyd Andrew, Martin Jeffrey, Ahuja Seema S, Agan Brian K, Walker Bruce D, Deeks Steven G, Ahuja Sunil K

Abstract excerpt

Although host defense against human immunodeficiency virus 1 (HIV-1) relies mainly on cell-mediated immunity (CMI), the determinants of CMI in humans are poorly understood. Here we demonstrate that variations in the genes encoding the chemokine CCL3L1 and HIV coreceptor CCR5 influence CMI in both healthy and HIV-infected individuals. CCL3L1-CCR5 genotypes associated with altered CMI in healthy subjects were...

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Identifiers

PMID: 17952079
DOI: 10.1038/ni1521

Genes

CCR5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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