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Article

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.

Journal of neurochemistry - 1 Dec 2002

Arawaka Shigeki, Hasegawa Hiroshi, Tandon Anurag, Janus Christopher, Chen Fusheng, Yu Gang, Kikuchi Kenji, Koyama Shingo, Kato Takeo, Fraser Paul E, St George-Hyslop Peter

Abstract excerpt

Nicastrin, a type-I transmembrane glycoprotein, is a necessary component of the high molecular weight presenilin (PS) complexes that mediate intramembranous cleavage of beta-amyloid precursor protein (betaAPP) and Notch. Nicastrin undergoes trafficking-dependent glycosylation maturation, and PS1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12437577
DOI: 10.1046/j.1471-4159.2002.01207.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12437577-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The levels of mature glycosylated nicastrin are regulated and correlate with gamma-secretase processing of amyloid beta-precursor protein.PMID 12437577Read ↗

Complex N-glycosylated form of nicastrin is stabilized and selectively bound to presenilin fragments.Semantic proximity Read ↗

Overexpression of nicastrin increases Abeta production.Semantic proximity Read ↗

Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane.Semantic proximity Read ↗

Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.Semantic proximity Read ↗

Positive and negative regulation of the gamma-secretase activity by nicastrin in a murine model.Semantic proximity Read ↗

Mutations in nicastrin protein differentially affect amyloid beta-peptide production and Notch protein processing.Semantic proximity Read ↗

Nicastrin interacts with gamma-secretase complex components via the N-terminal part of its transmembrane domain.Semantic proximity Read ↗

Degradation of nicastrin involves both proteasome and lysosome.Semantic proximity Read ↗

Nicastrin binds to membrane-tethered Notch.Semantic proximity Read ↗

Drosophila nicastrin is essential for the intramembranous cleavage of notch.Semantic proximity Read ↗

Nicastrin is dispensable for gamma-secretase protease activity in the presence of specific presenilin mutations.Semantic proximity Read ↗

Nicastrin is required for Presenilin-mediated transmembrane cleavage in Drosophila.Semantic proximity Read ↗

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