Article
Binding of endostatin to endothelial heparan sulphate shows a differential requirement for specific sulphates.
The Biochemical journal - 1 Oct 2003
Blackhall Fiona H, Merry Catherine L R, Lyon Malcolm, Jayson Gordon C, Folkman Judah, Javaherian Kashi, Gallagher John T
Abstract excerpt
Endostatin is a naturally occurring proteolytic fragment of the C-terminal domain of collagen XVIII. It inhibits angiogenesis by a mechanism that appears to involve binding to HS (heparan sulphate). We have examined the molecular interaction between endostatin and HS from micro- and macrovessel endothelial cells. Two discrete panels of oligosaccharides were prepared from metabolically radiolabelled HS, using...
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