Article
Non-heparan sulfate-binding interactions of endostatin/collagen XVIII in murine development.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Feb 2005
Rychkova Natalia, Stahl Sonja, Gaetzner Sabine, Felbor Ute
Abstract excerpt
Knobloch syndrome is characterized by a congenital generalized eye disease and cranial defect. Pathogenic mutations preferentially lead to a deletion or functional alteration of collagen XVIII's most C-terminal endostatin domain. Endostatin can be released from collagen XVIII and is a potent inhibitor of angiogenesis and tumor growth. We show differential expression of binding partners for endostatin, vascular...
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