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Article

The clinical potential of antiangiogenic fragments of extracellular matrix proteins

1 Oct 2005

Abstract excerpt

Neovasculature development is a crucial step in the natural history of a cancer. While much emphasis has been placed on proangiogenic growth factors such as VEGF, it is clear that endogenous angiogenesis inhibitors also have critical roles in the regulation of this process. Recent research has identified several cryptic fragments of extracellular matrix/vascular basement membrane proteins that have potent...

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PMID: 16234821
DOI: 10.1038/sj.bjc.6602820

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