Article
CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor.
The Journal of cell biology - 1 Feb 1995
Bennett K L, Jackson D G, Simon J C, Tanczos E, Peach R, Modrell B, Stamenkovic I, Plowman G, Aruffo A
Abstract excerpt
Glycosaminoglycan-modified isoforms of CD44 have been implicated in growth factor presentation at sites of inflammation. In the present study we show that COS cell transfectants expressing CD44 isoforms containing the alternatively spliced exon V3 are modified with heparan sulfate (HS). Binding studies with three HS-binding growth factors, basic-fibroblast growth factor (b-FGF), heparin binding-epidermal growth...
Topics
- Alternative Splicing
- Antibodies, Monoclonal
- Base Sequence
- Carrier Proteins
- Dermatitis, Allergic Contact
- Endothelium, Vascular
- Enzyme-Linked Immunosorbent Assay
- Epidermal Growth Factor
- Exons
- Fibroblast Growth Factor 2