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Article

Endostatin's heparan sulfate-binding site is essential for inhibition of angiogenesis and enhances in situ binding to capillary-like structures in bone explants.

Matrix biology : journal of the International Society for Matrix Biology - 1 Jan 2005

Gaetzner Sabine, Deckers Martine M L, Stahl Sonja, Löwik Clemens, Olsen Bjorn R, Felbor Ute

Abstract excerpt

The functional role of endostatin's affinity for heparan sulfates was addressed using an ex vivo bone angiogenesis model. Capillary-like sprouts showed prominent expression of collagen XVIII/endostatin. Outgrowth of endothelial cells was not altered in the absence of collagen XVIII but inhibited by the addition of recombinant endostatin. Mutant non-heparan sulfate binding endostatin and the collagen XV endostatin...

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Share to Bone and Bones
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Dose-Response Relationship, Drug

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Share to Neovascularization, Pathologic

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Source

Identifiers

PMID: 15694132
DOI: 10.1016/j.matbio.2004.10.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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