Article
The common polymorphism of apolipoprotein E: geographical aspects and new pathophysiological relations.
Clinical chemistry and laboratory medicine - 1 May 2003
Gerdes Lars Ulrik
Abstract excerpt
Apolipoprotein E (apoE) has important functions in systemic and local lipid transport, but also has other functions. The gene (APOE) shows a common polymorphism with three alleles--APOE*2, APOE*3, and APOE*4. Their frequencies vary substantially around the world, but APOE*3 is the most common almost everywhere and is often considered to be the ancestral or "wild-type" allele for that reason. However, there are...
Topics
- Apolipoproteins E
- Gene Frequency
- Genetics, Population
- Genotype
- Geography
- Humans
- Polymorphism, Genetic
- Vitamin E Deficiency