Article
Apolipoprotein E (APOE) allele distribution in the world. Is APOE*4 a 'thrifty' allele?
Annals of human genetics - 1 Jul 1999
Corbo R M, Scacchi R
Abstract excerpt
Apolipoprotein E (APOE = gene, apoE = protein) plays a central role in plasma lipoprotein metabolism and in lipid transport within tissues. The APOE shows a genetic polymorphism determined by three common alleles, APOE*2, APOE*3, APOE*4 and the product of the three alleles differs in several functional properties. APOE is involved in the development of certain pathological conditions. In particular, the APOE*4...
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