Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human-derived vascular smooth muscle cells produce angiotensin II by changing to the synthetic phenotype.

Journal of cellular physiology - 1 Aug 2003

Hu Wen-Yang, Fukuda Noboru, Ikeda Yukihiro, Suzuki Ryo, Tahira Yosiko, Takagi Hiroto, Matsumoto Koichi, Kanmatsuse Katsuo, Mugishima Hideo

Abstract excerpt

We investigated whether vascular smooth muscle cells (VSMC)-derived from human produce angiotensin (Ang) II upon change from the contractile phenotype to the synthetic phenotype by incubation with fibronectin (FN). Expression of alpha-smooth muscle (SM) actin, apparent in the contractile phenotype, was decreased by FN. Expressions of matrix Gla and osteopontin, apparent in the synthetic phenotype, were increased...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiotensin-Converting Enzyme Inhibitors
Share to Angiotensin II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cathepsin D

Share to Cathepsins

Share to Fibronectins

Share to Oligonucleotides, Antisense

Share to Oligopeptides

Share to Serine Proteinase Inhibitors

Source

Identifiers

PMID: 12811821
DOI: 10.1002/jcp.10299

Genes

ACE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human-derived vascular smooth muscle cells produce angiotensin II by changing to the synthetic phenotype.PMID 12811821Read ↗

Phenotypic modulation by fibronectin enhances the angiotensin II-generating system in cultured vascular smooth muscle cells.Semantic proximity Read ↗

Growth characteristics, angiotensin II generation, and microarray-determined gene expression in vascular smooth muscle cells from young spontaneously hypertensive rats.Semantic proximity Read ↗

Contribution of synthetic phenotype on the enhanced angiotensin II-generating system in vascular smooth muscle cells from spontaneously hypertensive rats.Semantic proximity Read ↗

Phenotype and function of smooth muscle cells derived from the human normal great saphenous vein in response to hypoxia.Semantic proximity Read ↗

Angiopoietin‐2 regulates the phenotypic switch of vascular smooth muscle cellsSemantic proximity Read ↗

Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type.Semantic proximity Read ↗

[Gly14]-Humanin inhibits an angiotensin II-induced vascular smooth muscle cell phenotypic switch via ameliorating intracellular oxidative stress.Semantic proximity Read ↗

Association of smooth muscle cell phenotypes with extracellular matrix disorders in thoracic aortic dissection.Semantic proximity Read ↗

The expression of tissue factor and tissue factor pathway inhibitor in aortic smooth muscle cells is up-regulated in synthetic compared to contractile phenotype.Semantic proximity Read ↗

Nitric oxide--cyclic GMP pathway regulates vascular smooth muscle cell phenotypic modulation: implications in vascular diseases.Semantic proximity Read ↗

Phenotypic switching of vascular smooth muscle cells in animal model of rat thoracic aortic aneurysm.Semantic proximity Read ↗

Type I collagen promotes modulation of cultured rabbit arterial smooth muscle cells from a contractile to a synthetic phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.