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Article

Nicotine exposure alters human vascular smooth muscle cell phenotype from a contractile to a synthetic type.

Atherosclerosis - 1 Dec 2014

Yoshiyama Shinji, Chen Zhenyi, Okagaki Tsuyoshi, Kohama Kazuhiro, Nasu-Kawaharada Ritsuko, Izumi Takashi, Ohshima Noriyasu, Nagai Takeharu, Nakamura Akio

Abstract excerpt

OBJECTIVE: Cigarette smoking is a known risk factor for arteriosclerosis. In atheromatous plaques, vascular smooth muscle cells (VSMCs) display a phenotype that is different from the contractile type under normal conditions. Nicotine is the major pharmacological agent in cigarette smoke. However, any direct effect of nicotine on VSMCs remains uncertain. Because nicotine promotes VSMC migration, its phenotype may...

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Source

Identifiers

PMID: 25463075
DOI: 10.1016/j.atherosclerosis.2014.10.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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