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Article

Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Feb 2009

Gerner Eugene W, Meyskens Frank L

Abstract excerpt

Increased polyamine synthesis and inflammation have long been associated with colon carcinogenesis in both preclinical models and in humans. Recent experimental studies suggest that polyamines may be mechanistically involved in colonic inflammatory processes. Genetic epidemiology results indicate that a single nucleotide polymorphism influencing the expression of a polyamine biosynthetic gene is associated with...

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Identifiers

PMID: 19188144
DOI: 10.1158/1078-0432.CCR-08-2235
PMCID: PMC2666541

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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