Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations.

doi:10.1093/jnci/djt331

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Article

Aspirin use, 8q24 single nucleotide polymorphism rs6983267, and colorectal cancer according to CTNNB1 alterations.

Journal of the National Cancer Institute - 18 Dec 2013

Nan Hongmei, Morikawa Teppei, Suuriniemi Miia, Imamura Yu, Werner Lillian, Kuchiba Aya, Yamauchi Mai, Hunter David J, Kraft Peter, Giovannucci Edward L, Fuchs Charles S, Ogino Shuji, Freedman Matthew L, Chan Andrew T

Abstract excerpt

BACKGROUND: Regular aspirin use reduces the risk for colorectal cancer (CRC), possibly through inhibition of WNT/cadherin-associated protein β1 (CTNNB1 or β-catenin) signaling. The single nucleotide polymorphism (SNP) rs6983267 on chromosome 8q24 is a CRC susceptibility locus that affects binding activity of transcription factor 7 like-2 (TCF7L2) to CTNNB1, thereby altering expression of target oncogenes,...

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PMID: 24317174
DOI: 10.1093/jnci/djt331
PMCID: PMC3866156

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CTNNB1
MYC

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