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Article

Associations of a polymorphism in the ornithine decarboxylase gene with colorectal cancer survival.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2009

Zell Jason A, Ziogas Argyrios, Ignatenko Natalia, Honda Jane, Qu Ning, Bobbs Alexander S, Neuhausen Susan L, Gerner Eugene W, Anton-Culver Hoda

Abstract excerpt

PURPOSE: Activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is required for normal growth and is elevated in many cancers, including colorectal cancer. We examined associations of the +316 ODC1 single nucleotide polymorphism (SNP) with colorectal cancer-specific survival among colorectal cancer cases, and then investigated its functional significance in colon cancer cells....

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Identifiers

PMID: 19789310
DOI: 10.1158/1078-0432.CCR-09-0592
PMCID: PMC2769500

Genes

ODC1
MYC

Provenance

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