Article
Interaction between the two conserved single-stranded regions at the decoding site of small subunit ribosomal RNA is essential for ribosome function.
Biochemistry - 8 Dec 1992
Cunningham P R, Nurse K, Bakin A, Weitzmann C J, Pflumm M, Ofengand J
Abstract excerpt
Formation of the tertiary base pair G1401:C1501, which brings together two universally present and highly sequence-conserved single-stranded segments of small subunit ribosomal RNA, is essential for ribosome function. It was previously reported that mutation of G1401 inactivated all in vitro functions of the ribosome [Cunningham et al. (1992) Biochemistry 31, 7629-7637]. Here we show that mutation of C1501 to G...
Topics
- Base Sequence
- Binding Sites
- Cross-Linking Reagents
- Escherichia coli
- Molecular Sequence Data
- Mutation
- N-Formylmethionine
- Nucleic Acid Conformation
- RNA, Bacterial
- RNA, Ribosomal, 16S