Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational analysis of the conserved bases C1402 and A1500 in the center of the decoding domain of Escherichia coli 16 S rRNA reveals an important tertiary interaction.

Journal of molecular biology - 4 May 2001

Vila-Sanjurjo A, Dahlberg A E

Abstract excerpt

Interactions within the decoding center of the 30 S ribosomal subunit have been investigated by constructing all 15 possible mutations at nucleotides C1402 and A1500 in helix 44 of 16 S rRNA. As expected, most of the mutations resulted in highly deleterious phenotypes, consistent with the high degree of conservation of this region and its functional importance. A total of seven mutants were viable under...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoglycosides
Share to Drug Resistance, Microbial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Methylation

Share to Methyltransferases

Share to Protein Subunits

Share to Ribosomes

Share to RNA, Bacterial

Share to Suppression, Genetic

Source

Identifiers

PMID: 11327780
DOI: 10.1006/jmbi.2001.4576

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational analysis of the conserved bases C1402 and A1500 in the center of the decoding domain of Escherichia coli 16 S rRNA reveals an important tertiary interaction.PMID 11327780Read ↗

Functional effects of base changes which further define the decoding center of Escherichia coli 16S ribosomal RNA: mutation of C1404, G1405, C1496, G1497, and U1498.Semantic proximity Read ↗

Mutations in 16S rRNA in Escherichia coli at methyl-modified sites: G966, C967, and G1207.Semantic proximity Read ↗

Tertiary interactions between helices h13 and h44 in 16S RNA contribute to the fidelity of translation.Semantic proximity Read ↗

30S subunit recognition and G1405 modification by the aminoglycoside-resistance 16S ribosomal RNA methyltransferase RmtCSemantic proximity Read ↗

Structure and function of the conserved 690 hairpin in Escherichia coli 16 S ribosomal RNA: analysis of the stem nucleotides.Semantic proximity Read ↗

Contribution of 16S rRNA nucleotides forming the 30S subunit A and P sites to translation in Escherichia coli.Semantic proximity Read ↗

Epistasis analysis of 16S rRNA ram mutations helps define the conformational dynamics of the ribosome that influence decoding.Semantic proximity Read ↗

Role of conserved nucleotides in building the 16 S rRNA binding site for ribosomal protein S15.Semantic proximity Read ↗

Interaction between the two conserved single-stranded regions at the decoding site of small subunit ribosomal RNA is essential for ribosome function.Semantic proximity Read ↗

Phenotypic heterogeneity of mutational changes at a conserved nucleotide in 16 S ribosomal RNA.Semantic proximity Read ↗

Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction.Semantic proximity Read ↗

Pleiotropic effects of mutations at positions 13 and 914 in Escherichia coli 16S ribosomal RNA.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.