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Article

Abl family kinases and Cbl cooperate with the Nck adaptor to modulate Xenopus development.

The Journal of biological chemistry - 17 Nov 2000

Adler C E, Miyoshi-Akiyama T, Aleman L M, Tanaka M, Smith J M, Mayer B J

Abstract excerpt

We previously showed that overexpression of the Nck Src homology (SH) 2/SH3 adaptor in Xenopus embryos induced developmental defects including anterior truncation and mesoderm ventralization. Mutagenic analysis indicated that this was due to relocalization of endogenous proteins that bind the first two SH3 domains of Nck. We therefore screened a Xenopus expression library with Nck SH3 domains to identify...

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PMID: 10967110
DOI: 10.1074/jbc.M005424200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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