Article
Loss of Sin3/Rpd3 histone deacetylase restores the DNA damage response in checkpoint-deficient strains of Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Jul 2003
Scott Kenneth L, Plon Sharon E
Abstract excerpt
We previously reported that expression of the human forkhead/winged helix transcription factor, CHES1 (checkpoint suppressor 1; FOXN3), suppresses sensitivity to DNA damage and restores damage-induced G(2)/M arrest in checkpoint-deficient strains of Saccharomyces cerevisiae. We find that a functional glutathione S-transferase-Ches1 fusion protein binds in vivo to Sin3, a component of the S. cerevisiae Sin3/Rpd3...
Topics
- Alleles
- Cell Cycle
- Cell Cycle Proteins
- Checkpoint Kinase 2
- DNA Damage
- Dose-Response Relationship, Drug
- Dose-Response Relationship, Radiation
- Enzyme Inhibitors
- Forkhead Transcription Factors
- G2 Phase
- Gene Deletion
- Glutathione Transferase
- Histone Deacetylases