Article
A role for Sds3p, a component of the Rpd3p/Sin3p deacetylase complex, in maintaining cellular integrity in Saccharomyces cerevisiae.
Molecular genetics and genomics : MGG - 1 May 2001
Vannier D, Damay P, Shore D
Abstract excerpt
The SDS3 gene was identified in a suppressor screen for mutations that enhance position-effect silencing in yeast. Cells that are defective in SDS3 have pleiotropic phenotypes, similar to those seen in the absence of the histone deacetylase components Rpd3p and Sin3p, including meiotic defects and improper regulation of the HO gene. To gain further insight into SDS3 function we undertook an epistasis analysis...
Topics
- Carboxylic Ester Hydrolases
- Cell Division
- Cell Wall
- Fungal Proteins
- Gene Deletion
- Genetic Complementation Test
- Histone Deacetylases
- Meiosis
- Mutation
- Phenotype
- Protein Binding