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Article

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.

Molecular biology of the cell - 1 Jun 2003

Kimata Yukio, Kimata Yuki I, Shimizu Yusuke, Abe Hiroshi, Farcasanu Ileana C, Takeuchi Masato, Rose Mark D, Kohno Kenji

Abstract excerpt

In the unfolded protein response (UPR) signaling pathway, accumulation of unfolded proteins in the endoplasmic reticulum (ER) activates a transmembrane kinase/ribonuclease Ire1, which causes the transcriptional induction of ER-resident chaperones, including BiP/Kar2. It was previously hypothesized that BiP/Kar2 plays a direct role in the signaling mechanism. In this model, association of BiP/Kar2 with Ire1...

Topics

Fungal Proteins
HSP70 Heat-Shock Proteins
Membrane Glycoproteins
Mutation
Protein Folding
Protein Serine-Threonine Kinases
Saccharomyces cerevisiae
Saccharomyces cerevisiae Proteins
Transcription, Genetic
Up-Regulation

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Identifiers

PMID: 12808051
DOI: 10.1091/mbc.e02-11-0708
PMCID: PMC194903

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