Article
Loss of BiP/GRP78 function blocks translocation of secretory proteins in yeast.
The Journal of cell biology - 1 Jun 1990
Vogel J P, Misra L M, Rose M D
Abstract excerpt
BiP/GRP78 is an essential member of the HSP70 family that resides in the lumen of the endoplasmic reticulum. In yeast, BiP/GRP78 is encoded by the KAR2 gene. A temperature sensitive mutation was isolated in KAR2 and found to cause a rapid block in protein secretion. Secretory precursors of a numb...
Topics
- Alleles
- Animals
- Endoplasmic Reticulum
- Fungal Proteins
- HSP70 Heat-Shock Proteins
- Heat-Shock Proteins
- Mutation
- Phenotype
- Precipitin Tests
- Saccharomyces cerevisiae
- Temperature
- Translocation, Genetic