Article
Experimental approaches for elucidation of stress-sensing mechanisms of the IRE1 family proteins.
Methods in enzymology - 1 Jan 2011
Oikawa Daisuke, Kimata Yukio
Abstract excerpt
Endoplasmic reticulum (ER) stress, which is often regarded as the accumulation of unfolded proteins in the ER, triggers cellular protective events including the unfolded protein response (UPR). In the yeast S. cerevisiae, the UPR signaling pathway starts from the ER-located transmembrane protein Ire1, the activation of which eventually leads to transcriptional induction of various genes including those encoding...
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