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Article

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.

The Journal of cell biology - 8 Nov 2004

Kimata Yukio, Oikawa Daisuke, Shimizu Yusuke, Ishiwata-Kimata Yuki, Kohno Kenji

Abstract excerpt

In the unfolded protein response, the type I transmembrane protein Ire1 transmits an endoplasmic reticulum (ER) stress signal to the cytoplasm. We previously reported that under nonstressed conditions, the ER chaperone BiP binds and represses Ire1. It is still unclear how this event contributes to the overall regulation of Ire1. The present Ire1 mutation study shows that the luminal domain possesses two...

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Identifiers

PMID: 15520230
DOI: 10.1083/jcb.200405153
PMCID: PMC2172501

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A role for BiP as an adjustor for the endoplasmic reticulum stress-sensing protein Ire1.PMID 15520230Read ↗

Experimental approaches for elucidation of stress-sensing mechanisms of the IRE1 family proteins.Semantic proximity Read ↗

A chimeric mutant analysis in yeast cells suggests BiP independent regulation of the mammalian endoplasmic reticulum-stress sensor IRE1α.Semantic proximity Read ↗

Self-association and BiP dissociation are not sufficient for activation of the ER stress sensor Ire1.Semantic proximity Read ↗

The unfolded protein response supports cellular robustness as a broad-spectrum compensatory pathway.Semantic proximity Read ↗

ER stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stressSemantic proximity Read ↗

IRE1 and efferent signaling from the endoplasmic reticulumSemantic proximity Read ↗

Genetic evidence for a role of BiP/Kar2 that regulates Ire1 in response to accumulation of unfolded proteins.Semantic proximity Read ↗

Heat shock response relieves ER stress.Semantic proximity Read ↗

LHS1 and SIL1 provide a lumenal function that is essential for protein translocation into the endoplasmic reticulum.Semantic proximity Read ↗

XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein ResponseSemantic proximity Read ↗

SSI1 encodes a novel Hsp70 of the Saccharomyces cerevisiae endoplasmic reticulum.Semantic proximity Read ↗

Generic membrane-spanning features endow IRE1α with responsiveness to membrane aberrancy.Semantic proximity Read ↗

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