Characterizing the membrane recruitment domain of BDCPs and its role in gray platelet syndrome.

Abstract excerpt

BEACH domain-containing proteins (BDCPs) represent a family of large membrane-associated transmembrane cargo adaptors. In the current study, we determined the cryo-EM structure of the full-length typical BDCP NBEAL2, revealing an N-terminal arch-like structure with C-terminal globular domains attached to its convex surface. Using structure-guided deletion mutants and protein chimeras as well as native...

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• Adaptor Proteins, Vesicular Transport
• Blood Proteins
• Cell Membrane
• Cryoelectron Microscopy
• HEK293 Cells