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Article

Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.

Genetics - 1 Jun 2003

Laurençon Anne, Purdy Amanda, Sekelsky Jeff, Hawley R Scott, Su Tin Tin

Abstract excerpt

ATM/ATR kinases act as signal transducers in eukaryotic DNA damage and replication checkpoints. Mutations in ATM/ATR homologs have pleiotropic effects that range from sterility to increased killing by genotoxins in humans, mice, and Drosophila. Here we report the generation of a null allele of mei-41, Drosophila ATM/ATR homolog, and the use of it to document a semidominant effect on a larval mitotic checkpoint...

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Source

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Identifiers

PMID: 12807779
DOI: 10.1093/genetics/164.2.589
PMCID: PMC1462579

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR.PMID 12807779Read ↗

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