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Article

A pharmacological screen for compounds that rescue the developmental lethality of a Drosophila ATM mutant.

PloS one - 1 Jan 2018

Rimkus Stacey A, Wassarman David A

Abstract excerpt

Ataxia-telangiectasia (A-T) is a neurodegenerative disease caused by mutation of the A-T mutated (ATM) gene. ATM encodes a protein kinase that is activated by DNA damage and phosphorylates many proteins, including those involved in DNA repair, cell cycle control, and apoptosis. Characteristic biological and molecular functions of ATM observed in mammals are conserved in Drosophila melanogaster. As an example,...

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Source

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Identifiers

PMID: 29338042
DOI: 10.1371/journal.pone.0190821
PMCID: PMC5770031

Genes

ATM

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Source receipt: pubmed, retrieved 7 Sept 2026.

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