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Article

Effects of mutant ubiquitin on ts1 retrovirus-mediated neuropathology.

Journal of virology - 1 Jul 2003

Zhang Mei, Thurig Sherry, Tsirigotis Maria, Wong Paul K Y, Reuhl Kenneth R, Gray Douglas A

Abstract excerpt

ts1 is a temperature-sensitive mutant of Moloney murine leukemia virus that induces a rapid spongiform encephalopathy in mice infected as newborns. The pathological features include the formation of ubiquitinated inclusions resembling Lewy bodies. To determine how perturbation of the ubiquitin-proteasome pathway might affect ts1-mediated neurodegeneration, the virus was introduced into transgenic mice in which...

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Identifiers

PMID: 12805418
DOI: 10.1128/jvi.77.13.7193-7201.2003
PMCID: PMC164816

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Source receipt: pubmed, retrieved 7 Sept 2026.

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