Article
Protective effects of mutant ubiquitin in transgenic mice.
Annals of the New York Academy of Sciences - 1 Jun 2004
Gray D A, Tsirigotis M, Brun J, Tang M, Zhang M, Beyers M, Woulfe J
Abstract excerpt
The K48R mutant ubiquitin can exert profound in vivo protective effects against a variety of insults, including agents of direct clinical relevance. The manipulation of the ubiquitin/proteasome pathway has enormous potential for clinical benefit, and it is not unreasonable to expect that such benefits will include diseases of aging.
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