Article
Membrane targeting of Rab GTPases is influenced by the prenylation motif.
Molecular biology of the cell - 1 May 2003
Gomes Anita Q, Ali Bassam R, Ramalho Jose S, Godfrey Richard F, Barral Duarte C, Hume Alistair N, Seabra Miguel C
Abstract excerpt
Rab GTPases are regulators of membrane traffic. Rabs specifically associate with target membranes via the attachment of (usually) two geranylgeranyl groups in a reaction involving Rab escort protein and Rab geranylgeranyl transferase. In contrast, related GTPases are singly prenylated by CAAX prenyl transferases. We report that di-geranylgeranyl modification is important for targeting of Rab5a and Rab27a to...
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