Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases.

doi:10.1042/bj3330497

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Article

Prenylation of Rab8 GTPase by type I and type II geranylgeranyl transferases.

The Biochemical journal - 1 Aug 1998

Wilson A L, Erdman R A, Castellano F, Maltese W A

Abstract excerpt

Rab GTPases are post-translationally modified by addition of geranylgeranyl moieties to carboxyl-terminal cysteine residues. For Rab proteins ending with xxCC xCxC and CCxx motifs this modification is catalysed by geranylgeranyltransferase type II (GGTaseII), and is entirely dependent on the Rab...

Topics

Adaptor Proteins, Signal Transducing
Alkyl and Aryl Transferases
Carrier Proteins
Enzyme Inhibitors
GTP Phosphohydrolases
GTP-Binding Proteins
Humans
Mutation
Protein Prenylation
Substrate Specificity
Transferases
rab GTP-Binding Proteins

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