Article
Myristoylation cannot functionally replace the isoprenylation of Rab5.
Archives of biochemistry and biophysics - 10 Jan 1995
Li G, Barbieri M A, Stahl P D
Abstract excerpt
C-terminal isoprenylation is necessary for the small GTPase Rab5 to associate with early endosomes and to exert its regulatory function in endocytosis. In this study, we tested whether Rab5 could retain its membrane association and biological function if the isoprenylation were replaced by anothe...
Topics
- Animals
- Base Sequence
- Biological Transport
- Biomarkers
- Cells, Cultured
- Cricetinae
- Diterpenes
- Endocytosis
- GTP-Binding Proteins
- Gene Products, gag
- Horseradish Peroxidase
- Membranes
- Molecular Sequence Data
- Mutation
- Myristic Acid
- Myristic Acids
- Protein Prenylation
- Protein Processing, Post-Translational